New technology to manipulate CRISPR gene editing system — science and technology stellarium

A new technology to control CRISPR gene editing system — technology — people.com.cn original title: the new technology to control CRISPR gene editing system – the latest discovery and innovation 973 project chief scientist Francis Choi Shenzhen No.2 People’s Hospital, Liu Yuchen and Huang Weiren on CRISPR-Cas9 gene editing system to improve and perfect, the realization of Cas9 control, can control the signal flow direction of cancer cells. Effective intervention on cancer cells of various "malignant" behavior. The results of the study were published online September 5th in the British journal Nature methodology. CRISPR – Cas9 system developed rapidly in recent years with strong gene editing and control capabilities, through the precise "guidance" of sgRNA and Cas9 nuclease target implementation operation to achieve the functions of gene editing and synergistic regulation ability. This system has been widely used in many fields, such as life science and medicine. However, there are still many problems to be solved in the process of application, such as avoiding "out of control" and "over editing". Traditional methods mainly use external "power" to destroy cancer cells, but often damage innocent cells, causing great side effects. The mutation causes abnormal cell signal transduction of cancer, researchers used new technology to control the signal flow direction in the cancer cells, a variety of effective intervention "cells of malignant behavior, these cells start their death program. The researchers, is a kind of tumor due to mutations and diseases caused by abnormal intracellular signal transduction networks, the traditional treatment methods such as chemotherapy, kill cancer cells at the same time, often cause great damage to normal cells, side effects. This new set of tools can be perceived inside cancer cells or molecules upstream abnormal exogenous signaling molecule, and at the same time with downstream of multiple tumor suppressor molecules to form a new "signal transduction network", and then start their own death program, because normal cells do not exist cancer cell specific molecules, can not be affected by this. The traditional research method in the past is not easy to achieve. (reporter Wang Yi) (commissioning editor Hao Mengjia and Zhao Zhuqing)相关的主题文章: